Active folate for mood, heart health, fetal development, and nerve support
5-MTHF is an active, tissue-ready form of folate. It’s an essential B vitamin that supports methylation. Many individuals don’t get sufficient 5-MTHF because they have intestinal or liver dysfunction or because of their genetic makeup.
5-MTHF (5-methyltetrahydrofolate) is a form of folate, a B-vitamin that is important for many bodily functions. Folate is essential for DNA synthesis and repair, as well as the production of red blood cells and the metabolism of proteins and other nutrients. 5-MTHF is the most active form of folate in the body and is used to treat folate deficiency, as well as certain neurological disorders, heart disease, and other health conditions. It is available as a dietary supplement and can also be prescribed by a doctor.
Many individuals don’t get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF. A deficiency of folic acid has been linked to low-birth-weight infants and neural tube defects, which is why the Centers for Disease Control recommends folic acid supplementation for all women of childbearing age. Since 5-MTHF also contributes to the production of serotonin, melatonin, dopamine, epinephrine, and norepinephrine, supplementation supports healthy mood.
Note: 1 mg of 5-MTHF is recommended for fetal support during pregnancy; the 15 mg option is recommended only when directed by a health-care practitioner.
It is important for a woman of childbearing age to get enough folic acid – not just those women who are planning to become pregnant. Because half of pregnancies are unplanned, any woman who could become pregnant should get enough folic acid every day. Folic acid intake is especially important before conception and during early pregnancy, since its biggest need is during the first trimester – when a woman might not even know she is pregnant. Supplementation with the active form of folic acid – 5-MTHF (L-5 Methyltetrahydrofolate)– is always preferable.
Acting with vitamin B12, 5-MTHF functions as a methyl-group donor, thereby facilitating the conversion of the amino acid homocysteine to methionine. An elevated homocysteine level is a risk factor for a number of undesirable health conditions. Methyl-group donation is vital to many biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA.
One Capsule Contains:
Folate (1 mg as L-5-Methyltetrahydrofolate†) 1.7 mg DFE
Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.
†This product uses Gnosis S.p.A.’s L-5-Methyltetrahydrofolate (Extrafolate-S®). Extrafolate-S is a registered trademark of Gnosis S.p.A.
Take 1 capsule one to three times daily or as recommended by your health professional.
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
If pregnant, consult your health professional before using this product.
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate’s anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.read more
L-Methylfolate (Standalone Formula), Support positive mood and emotional well-being.
Based on scientific research, MethylPro L-methylfolate is a more active and bioavailable form of folate and is the only form of folate to cross the blood-brain barrier. For optimal purity, the amino acid glycine is the only additional ingredient.
Folate is important for the normal production of the mood balancing neurotransmitters serotonin, norepinephrine and dopamine. Folic acid is the most common form of folate in supplements and fortified foods but it needs to be converted to methylfolate to be used by the body for neurotransmitter communication and many other important biochemical reactions. This process is done by the enzyme, methylenetetrahydrofolate reductase (MTHFR). Unfortunately, about half the population have genetic variations that reduce the ability of the MTHFR enzyme to convert folic acid to its usable form, methylfolate. Because supplementing with L-methylfolate removes the need for this conversion, it is far more effective than its inactivated counterparts.read more